2021, by Walter Isaacson, Kindle version, Simon & Shuster
I was amazed by this book and the discoveries that it described. I was also impressed by the accomplishments of the female scientists, Jennifer Doudna and Emmanuel Charpientier among others. Our society seems to value celebrities such as the Kardashians and Brittany Spears so much. At the same time, if I ask my friends and acquaintances if they know who Jennifer Doudna is, most have never heard of her, despite her having discovered perhaps the most revolutionary scientific discovery of our times and received the Nobel Prize in chemistry in 2020. This is really too bad.
Isaacson traces the discovery of the CRISPR gene editing process by Doudna and others and provides biographical information on many scientists who have played a role in that discovery. This is a world that is entirely foreign to me and it was interesting to dive into. More importantly, however, is the potential of this discovery to not only cure some of the diseases that afflict so many individuals, but it also has had a profound impact in the development of the mRNA Covid vaccines. It may, in fact, be the solution to combating all viruses in the future.
It seems that Isaacson inserts himself into the narrative a lot which is probably a result of his research and interviews that he undertook to write the book. Usually an author keeps himself at a distance, but this was not the case in The Code Breaker. Although he does a great job in chronicling Doudna’s accomplishments and career, I didn’t seem to get a feel for her as a person. It seems that she is a pretty private individual.
Isaacson spends about four chapters discussing the ethics of various applications of gene editing. While these chapters were not the most interesting in the book, I believe the discussion was necessary to put the possible consequences of these discoveries on the table.
In summary, I was blown away by the complexity of these discoveries and the sheer brilliance of the scientists who are working in this field. I highly recommend this book to anyone who is curious about what is going on in the realm of biochemistry.